|
|
|
Literature Cited 1. Martucci CP, Fishman J. (1979), Impact of continuously administered catechol estrogens in uterine growth and luteinizing hormone secretion. Endocrinology 105:1288-1292. 2. Schneider J, Huh MM, Bradlow HL,Fishman J. (1984), Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem 259:4840-4845. 3. Vandewalle B, Lefebvre J. (1989), Opposite effects of estrogen and catechol estrogen on hormone-sensitive breast cancer cell growth and differentiation. Mol Cell Endocrinol 61:239-246. 4. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. (1996), 2-hydroxyestrone: the ‘good’ estrogen. J Endocrinol 150:Suppl: S259-S265. 5. Fishman J, Martucci C. (1980), Biological properties of 16alpha-hydroxyestrone: Implications in estrogen physiology and pathophysiology. J Clin Endocrinol Metab 51:611-615. 6. Swaneck GE, Fishman J. (1988), Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: Characterization and intranuclear localization. Proc Natl Acad Sci ,USA 85:7831-7835. 7. Yu SC, Fishman J. (1985), Interaction of histones with estrogens. Covalent adduct formation with 16alpha-hydroxyestrone. Biochemistry 24:8017-8021. 8. Miyairi S, Ichikawa T,Nambara T. (1991), Structure of the adduct of 16 a-hydroxyestrone with a primary amine: evidence for the Heyns rearrangement of steroidal d-ring a-hydroxyimines. Steroids 56:361-366.9. Lustig RH, Mobbs CV, Pfaff DW, Fishman J. (1989), Temporal actions of 16a-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites and between sexes. J Steroid Biochem Molec Biol 33:417-421. 10. Schneider J, Kinne D, Fracchia A, Pierce V, Anderson KE, Bradlow HL, Fishman J. (1982), Abnormal oxidative metabolism of estradiol in women with breast cancer. Proc Natl Acad Sci ,USA 79:3047-3051. 11. Osborne MP, Bradlow HL, Wong GYC, Telang NT. (1993), Upregulation of estradiol C16a -hydroxylation in human breast tissue: a potential biomarker of breast cancer risk. J Natl Cancer Inst 85:1917-1920. 12. Telang NT, Inoue S, Bradlow HL, Osborne MP. (1997), Negative growth regulation of oncogene transformed mammary epithelial cells by tumor inhibitors. Adv Exp Med Biol 400A:409-418. 13. Bradlow HL, Hershcopf RJ, Martucci CP,Fishman J. (1985), Estradiol 16a-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: A possible model for the hormonal etiology of breast cancer in humans. Proc Natl Acad Sci ,USA 82:6295-6299. 14. Telang NT, Axelrod DM, Wong GY, Bradlow HL,Osborne MP. (1995), Biotransformation of estradiol by explant culture of human mammary tissue. Steroids 56:37-43. 15. Telang NT, Bradlow HL, Kurihara H,Osborne MP. (1989), In vitro biotransformation of estradiol by explant cultures of murine mammary tissues. Br Cancer Res Treat 13:173-181. 16. Telang NT, Narayanan R, Bradlow HL,Osborne MP. (1991), Coordinated expression of intermediate biomarkers for tumorigenic transformation in ras-transfected mouse mammary epithelial cells. Br Cancer Res Treat 1991; 18:155-163. 17. Telang NT, Suto A, Wong GY, Osborne MP,Bradlow HL. (1992), Estrogen metabolite 16a-hydroxyestrone induces genotoxic damage and aberrant cell proliferation in mouse mammary epithelial cells in culture. J Natl Cancer Inst 82:634-638. 18. Arts CJ, Wilmer JW, de Bie AT, van den Berg H. (1990), In vitro synthesis of 16alpha-.hydroxyestrone by female rat liver microsomes: possible role in the etiology of breast cancer. J Steroid Biochem 36: 527-531. 19. Klug TL, Bradlow HL, Sepkovic DW.(1994), Monoclonal antibody-based enzyme immunoassay for simultaneous quantitation of 2- and 16a -hydroxyestrone in urine. Steroids 59:648-655. 20. Luo XW, Ng EH, Foo SC, Jeyaratnam J. (1995), The ratio of urinary 2-hydroxyestrone and 16 alpha-hydroxyestrone (2/16(OHE1): a potential risk marker for breast cancer. 12th Asian Pacific Cancer Conference , Singapore, October 17-20, Abstract, p. 62. 21. Sepkovic DW, Bradlow HL, Ho G, Hankinson S, Gong L, Osborne MP, Fishman J. (1995), Estrogen metabolite ratios and risk assessment of hormone related cancers : assay validation and prediction of cervical cancer risk. Ann New York Acad Sci 768:312-316. 22. Kall MA, Vang O, Clausen J. (1996), Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone, and chlorzoxazone metabolism. Carcinogenesis 17: 793-799. 23. Kabat GC, Chang CJ, Sparano JA, Sepkovic DW, Hu XP, Khalil A, Rosenblatt R, Bradlow HL. (1997), Urinary estrogen metabolites and breast cancer: a case-control study. Cancer Epidemiol Biomark Prev 6: 505-509. 24. Ho GH, Luo XW, Ji CY, Foo SC, Ng GH. (1998), Using 2/16 alpha-hydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein-3 and a potential biomarker of breast cancer risk. Ann Acad Med Singapore 27: 294-299. 25. Taioli E, Garte SJ, Trachman J, Garbers S, Sepkovic DW, Osborne MP, Mehl S, Bradlow HL. (1996), Ethnic differences in estrogen metabolism in healthy women. J Natl Cancer Inst 88: 617. 26. Taioli E, Trachman J, Chen X, Toniolo P, Garte SJ. (1995), A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women. Cancer Res 55:3757-3758. 27. Taioli E, Trachtman J, Chen X, Sepkovic DW, Bradlow HL, Toniolo P. (1996), Correlation of estradiol 2-hydroxylation and breast cancer risk in patients carrying the MSP-1 polymorphism of CyP4501A1. Proc Amer Soc Cancer Res 37: Abstract 1697, p 249. 28. Coker AL, Crane MM, Sticca RP, Sepkovic DW. (1997), Correspondence, Re: Ethnic differences in estrogen metabolism in healthy women. J Natl Cancer Inst 89: 89. 29. Michnovicz JJ, Bradlow HL. (1990), Induction of estradiol metabolism by dietary indole-3-carbinol in humans. J Natl Cancer Inst 50:947-950. 30. Wong GY, Bradlow HL, Sepkovic D, Mehl S, Mailman J, Osborne MP. (1997), Dose- ranging study of indole-3-carbinol for breast cancer prevention. J Cell Biochem Suppl 28-29:111-116. 31. Michnovicz JJ, Galbraith RA. (1990), Effects of exogenous thyroxine on C-2 and C-16 hydroxylations of estradiol in humans. Steroids 55:22-26. 32. Michnovicz JJ, Naganuma H, Hershcopf RJ, Bradlow HL, Fishman J. (1988), Increased urinary catechol estrogen excretion in female smokers. Steroids 52:69-83. 33. Michnovicz JJ, Naganuma H, Hershcopf RJ, Bradlow HL, Fishman J. (1986), Increased 2-hydroxylaton of estradiol as a possible mechanism for the antiestrogenic effect of cigarette smoking. N Engl J Med 315:1305-1319. 34. Galbraith RA, Michnovicz JJ. (1989), The effects of cimetidine on the oxidative metabolism of estradiol. N Engl J Med 321:269-274. 35. Rosen CA, Woodson GE, Thompson JW, Hengesteg AP, Bradlow HL. (1998), Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck 118: 810-815. 36. Hodge J, Roodman-Weiss J, Lyss C, Wagner D, Klug T, Civitelli R. (1995), Increased inactive estrogen metabolites in urine of early postmenopausal women with low bone density. J Bone Miner Res 10:Suppl 1: S444. 37. Leelawattana R, Ziambara K, Lyss C, Roodman-Weiss J, Wagner D, Klug T, CivitelliR. (1997), Estrogen metabolites in urine of early postmenopausal women correlate with bone density. J Bone Miner Res 12:Suppl 1: 118. 38. Westerlind K, Gibson KJ, Malone P, Evans GL, Turner RT. (1998), Differential effects of estrogen metabolites on bone and reproductive tissues of ovarectomized rats. J Bone Miner Res 13: 1021-1031. |
|
Estrogen Metabolism
|
||||
| Figure 1 | 2/16 Pathway | Studies with Estramet | Literature Cited | ||||
|
2007. Immuna Care Corporation. |
||||